Caleva Blog

Mixed solvent system as binder for the production of silicified microcrystalline cellulose‐based pellets

… Then the wet mass was extruded immediately with a radial extruder (Model 20 Extruder, Caleva Ltd, UK) that was fitted with a screen of 150 mm in diameter and 1.0 mm die holes. The extruder screen rotated at 30 rpm. After …

Agglomeration properties of gluten-free flours under water addition and shearing conditions

The different states of agglomeration were identified by the evolution of rheological properties under water addition and shearing conditions using a Caleva® mixer torque rheometer. 

Biomation visit to Caleva

Our long-time friend and partner Mr Moritz Schlotterbeck of BIOMATION Wissenschaftliche Geräte GmbH visited Caleva yesterday to discuss our work together in the pharma and catalyst fields, and in particular an exciting new opportunity in a development using activated carbon and the processes of extrusion and spheronization.  We also discussed a joint presentation of our variable density...

Caleva Mini Coater Drier Helps to Reintroduce Endangered Native Australian Animals

Many experts recognise Caleva as a leading manufacturer in extrusion and spheronization equipment for the development of pharmaceutical formulations, catalysts and ceramics. However, the broard scope and flexibility of Caleva equipment provides diverse capabilities that is leading to emerging applications in implant manufacture and conservation science. To explain more, we caught up with Dr...

MGB

Does the Caleva Mixer/Granulator/Blender allow me to mix and test small batches of product?

We are frequently asked for information about the ability of the small mixer/granulator/blender, a must have tool for any laboratory needing to complete these processes quickly with small sample sizes. Recent trials provide new information about the the capability of the Caleva mixer/granulator/blender (MGB) and its ability to act as a stand alone mixer when mixing powder samples of different...

Mini Coater Drier support at Dai Nam University Vietnam

Mini Coater Drier support at Dai Nam University VietnamHỗ trợ kỹ thuật tại đại học Đại NamThe exclusive Caleva representative in Vietnam (ATI)* recently installed a Caleva Mini Coater Drier (Caleva MCD) in Dai Nam University Pharmaceutical Department (Hanoi – Vietnam). Dr Steve Robinson (Caleva) and with Mr Hung Nguyen (from ATI) recently made a follow-up visit following the installation some...

How can I be sure that the trials and development work that I do will give me comparable results when I need to scale up to production sizes?

Scale up of the spheronization process is relatively well known and understood. All of the Caleva extrusion and spheronization equipment is designed with scale up in mind.Our range of screw extruders from have the ability to modify the density of your extrudate when this is important.
  • The smallest Caleva Multi Lab (CML) with an extruder attachment designed to work with batches as little of 20...

New installation at Tupras oil refinery in Turkey

 

Effect of spheronizer plate design on the spheronization of ketoprofen

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation...

Extrusion–spheronization a promising pelletization technique: In-depth review

Abstract

This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid, excipients, and...

Spheronized Pellets | Extended Release | Poorly Soluble Antiemetic Agent

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...

How reproducible can measurements be of something that is not homogeneous?

The MTR-3 uniquely offers a means of characterising the rheological properties of a wet granulation by providing a quantitative value of the consistency of the material tested. The more traditional hand squeeze test, previously widely used, to measure or compare granulations, is falling into disrepute and is no longer considered appropriate for modern day industrial production or research...

Yield problems in production and quality control

One of the strengths of the Caleva Mixer Torque Rheometer (MTR-3) is that it can be used to verify the properties of wet powder mass samples taken during production in large scale mixer/granulator systems. It can be used simply as a quality control tool on a regular basis or specifically as an aid to problem solving. Small samples can be taken directly from production and within two minutes a...

I have inconsistent extrusion & spheronization results with a difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield (weight of acceptable pellets as a % of weight of granulation made), and dissolution profile....

How the Mixer Torque Rheometer resolved a tablet friability issue

Caleva worked closely with a well known producer of food supplements made from natural materials, plant extracts and other natural food sources.  Their tablet formulations work well and this nutraceutical company has a good reputation for their products.  Generally they do not encounter problems with tablets breaking or disintegrating during manufacture, packing or storage.

Determination of moisture requirement to prepare spheroids by extrusion-spheronization

Spheroids are popularly used in the design of multi-particulate drug delivery systems. Extrusion and spheronization is commonly employed to manufacture spheroids in the pharmaceutical industry. It is a multiple-step manufacturing process which could be summarized into the flow chart as shown in Figure 1.

Save Time and Cost in Formulation Development

In the mid 1990’s, the field of pyrotechnics was limited mainly to applications in aircraft ordnance, fireworks and rock blasting. This has been developed to a highly advanced science and is an extensively used technology which finds application in spacecraft, aircraft and underwater vehicle systems. “Pyrotechnic “is defined as “explosive-actuated” and refers especially to devices in which...

"End Point Determination” Using the Caleva Mixer Torque Rheometer

A company wished to move a formulation currently undergoing product development from small scale laboratory (with batches of 50 grams) to the next stage for a larger scale batch trial of 100 kg (scale–up).  The development had been started using a small Caleva Multi Lab bench top mixer (maximum batch capacity 50 gram of wet mass). This development had been successful and now additional samples...

Do you have heat generation and associated issues with your Extrusion process?

When talking with customers who manage production scale extrusion, I am often asked to comment on the amount of heat generated and the issues that this can cause. In reality, heat generation is just something that we have to live with as all extrusion processing will generate heat. The amount of heat generated will vary depending on:

  • The formulation of the product
  • The rate of extrusion
  • The...

Practical Approach on Industrial Rheology and Rheometry - MCIK Annual Seminar

Join Caleva's partner MCIK for their annual seminar