During a recent business trip to Japan, our International Sales Manager, Steve Mate, visited the Department of Chemical Engineering at Osaka Metropolitan University to find out how the Mixer Torque Rheometer (MTR) is being used to further their research.
Investigating drug dissolution enhancement and controlled release of solid-liquid hybrid dosage form using Liqui-Pellet technology.
Discover how the Caleva Multi Lab was used to demonstrate the flexibility and potential of Liqui-Pellets as the next generation oral dosage form.
To meet GCLP requirements in research and development it is essential that your lab machines are functioning at the required standard, providing accurate, reliable, and repeatable results.
Discover how Caleva extrusion and spheronization equipment supported a university master’s student in his scientific breakthrough, resulting in his publication in a recognised industry journal.
At Caleva, we offer a variety of extruders to meet your needs, from laboratory scale extruders for research and development purposes, to pilot scale extruders and larger models for batch production environments.
Switch quickly between different materials with this easy to clean CE marked, top quality extrusion and spheronization system. An example of reliable and efficient British engineering at its best - this is the best option for your pellet production and is backed by the highly acclaimed support from Caleva Process Solutions.The Caleva system gives you the ability to vary the density of the...
The process of spheronization consists of four key steps:-
- To optimize and achieve the right binder addition & mixing time for your formulation
- Mixing or granulation - a mixer or granulator is required
- Extrusion - an extruder is required
- Spheronization - a spheronizer is required
- Drying and possibly coating - a coater and drier may be required
This is all made simple by the Caleva suite of R&D...
We are frequently asked for information about the ability of the smallmixer/granulator/blender, a must have tool for any laboratory needing to complete these processes quickly with small sample sizes. Recent trials provide new information about the capability of the Caleva mixer/granulator/blender (MGB) and its ability to act as a stand alone mixer when mixing powder samples of different sizes...
Are you interested in one of our products and would like to see it in action?
We provide free R&D system demonstrations live online via video conference wherever you are in the world.
Scott Humphries or Steve Mate (or both) will explain and demonstrate advanced equipment features and allow you to see the processes that you'd like to see and that are relevant to your work. It will be an ideal time...
An opportunity to shape and form catalyst materials/particles
Caleva have had some considerable success with working with the extrusion of small quantities of catalytic material using the Caleva Multi Lab. (the first steps of blending and mixing can also be completed in the same Multi Lab base machine)
Our customer, a major pharmaceutical, biotech & nutraceutical manufacturer with an extensive portfolio of products. For reasons of confidentiality we do not name them.
One of our Production Extruder & Spheronizer Systems for manufacturing on a large-scale was used in trials by the manufacturer, but the pellets produced were not acceptable. As the product was already registered, the composition...
We are often asked about the production capacity of our extrusion and spheronization systems. To provide this information there needs to be an understanding of the process parameters that will be used and that have been determined at the development stage. With that information, the advice that we give can be both meaningful and useful in the planning stages.If you have proven your concept at the...
What is Spheronization?
Spheronization is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.
Why Consider Spheronization?
The products produced from this process can be useful in several ways:
Shaped Catalyst Body Preparation. Zeolite HZSM-5 (ACS Materials, M38) was mixed as a dry powder with alumina (Sasol, Catapal D (Boehmite)) and the required amount of Milli-Q water to ensure an optimum solid-to-liquid ratio for extrusion (measured using a Mixer Torque Rheometer, Caleva). The paste, containing a ratio of 70:30 wt % zeolite:binder, was extruded using a Mini-Screw Extruder (Caleva),...
The MTR can process from 10g to 25 g of your material, depending on the formulation, meaning barely any material is wasted in experiments. The machine will very quickly tell you the ideal amount of liquid to add. The user may have a start point in mind but this may result in a formulation that is too wet or too dry. The iterations may be repeated, but this can be wasteful in terms of materials...
The Caleva Multi-Lab (CML) can Mix/Granulate, Extrude and Spheronize all in one base unit.
This article is about the Extruder attachment that comes with the CML.
The Multi-lab is capable of working with a variety of materials from catalysts and pharmaceuticals, to agricultural products.
The extrusion attachment on the CML is in the form of a single screw extruder. A variety of dies...
It is not possible to extrude and spheronize everything. Extrusion and spheronization can be used on a wide range of products and formulations. However, if you are having trouble extruding your formulations with the Caleva Multi Lab (CML) then please read this article.
Caleva offers extruder screws of different designs for use with the CML. If you are having issues with the CML then the first...