Knowledge Base

5 Reasons Why You Should Choose Caleva

At Caleva we want to help pioneering research and formulation scientists achieve results and we believe that our range of R&D machines should make achieving these results as easy as possible.

Investigating the Impact of Process Variables in Formulation Development

Discover how Caleva extrusion and spheronization equipment supported a university master’s student in his scientific breakthrough, resulting in his publication in a recognised industry journal.

How to Reduce Your Formulation Development Time

Discover how to cut your formulation development time in half with the Caleva Multi Lab and its wide range of variable density dies.

 

Measuring and monitoring your formulation

Did you know that the Mixer Torque Rheometer (MTR) is designed to carry out 3 separate experiments essential to your formulation development and production?

Formulation development with Caleva

The process of spheronization consists of four key steps:-

  • To optimize and achieve the right binder addition  & mixing time for your formulation
  • Mixing or granulation - a mixer or granulator is required
  • Extrusion - an extruder is required
  • Spheronization - a spheronizer is required
  • Drying and possibly coating - a coater and drier may be required

This is all made simple by the Caleva suite of R&D...

Book a live online demonstration with Caleva

Are you interested in one of our products and would like to see it in action?

We provide free R&D system demonstrations live online via video conference wherever you are in the world.

Scott Humphries or Steve Mate (or both) will explain and demonstrate advanced equipment features and allow you to see the processes that you'd like to see and that are relevant to your work. It will be an ideal time...

Caleva Study on the Importance of Granulation

Our customer, a major pharmaceutical, biotech & nutraceutical manufacturer with an extensive portfolio of products. For reasons of confidentiality we do not name them.

One of our Production Extruder & Spheronizer Systems for manufacturing on a large-scale was used in trials by the manufacturer, but the pellets produced were not acceptable. As the product was already registered, the composition...

A Brief Non-Technical Guide To Spheronization (Marumerization*)

What is Spheronization?

Spheronization is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.

Why Consider Spheronization?

The products produced from this process can be useful in several ways:

  • ...

Extrusion of small batches

The Caleva Multi-Lab (CML) can Mix/Granulate, Extrude and Spheronize all in one base unit.

This article is about the Extruder attachment that comes with the CML.

The Multi-lab is capable of working with a variety of materials from catalysts and pharmaceuticals, to agricultural products.

The Extruder

The extrusion attachment on the CML is in the form of a single screw extruder.  A variety of dies...

Possible issues with extrusion of small samples - how to resolve them

It is not possible to extrude and spheronize everything.  Extrusion and spheronization can be used on a wide range of products and formulations.  However, if you are having trouble extruding your formulations with the Caleva Multi Lab (CML) then please read this article.

Caleva offers extruder screws of different designs for use with the CML.  If you are having issues with the CML then the first...

Opportunities for Mixer Torque Rheometry

Wet granulations are a useful precursor to many solid dosage formulations and as such are widely used in the pharmaceutical industry. Because of the diverse nature of pharmaceutical materials, granulation is often employed as an intermediate process to enhance flow and compaction properties and improve the final product performance. The properties of a wet granule have a critical effect on the...

Extruder dies | all sizes | variable density | quadrilobe | trilobe

In the process of extrusion, having different dies available to process your product is key to increasing your chances of development success.  This is why we offer a large range of dies to help you find the best options for your formulation.

We offer die plates that are excellent for most uses, like our 1 x 1 mm die, however sometimes a more specialist die may be needed.  Our trilobe and...

Extrusion of catalyst and petrochemical materials

An opportunity in laboratory extrusion with catalyst material.  We have recently had some considerable success with one of our customers working with the extrusion of small quantities of catalytic material.

Extruding catalyst materials for petrochemical and adsorption products

In collaboration with some of its users, Caleva have recently been successful in extruding of small quantities of catalytic material using the Caleva Multi Lab (the first steps of blending and mixing can also be completed in the same multilevel base machine) whilst increasing the surface area/volume ratio of the extrudate produced.

The Caleva Multi Lab is faster and easier to clean

The Caleva Multi Lab (CML) is faster and easier to clean than any comparable bench-top extrusion & spheronization equipment.

The best results in the minimum time for your formulation development

 

Guide to the optimum diameter to length ratio of extrudate fragments

Is there a guide to the optimum Length to Diameter ratio of the extrudate fragments?

In the calculations used to demonstrate the data it is assumed that the extrudate is an infinitely long strand. In this case the length of the extrudate has no influence on the data shown. In reality, extrudate is not infinitely long and as the individual strands of the extrudate produced become shorter, the...

How do I ensure consistency during scale up?

Consistency Measurement

A direct consistency measurement of a small sample (generally around 40 g) taken from a process as it is ongoing.  This allows for accurate comparisons to be made quickly, accurately, and repeatable way.

Formulation development - determine optimum powder to binder ratio

Multiple Addition Test

Binder liquid is added to a dry powder mix and the consistency is measured as the mixing and addition of binder progresses.

The consistency of the mix is measured at regular periods so that the relationship between the amount of liquid binder added to the mix and the consistency in the resulting formulation can be accurately shown.

What type of pharmaceutical or catalyst extruder do I need?

All extrusion processes require the generation of pressure within the material to be extruded. When materials are put under pressure heat is generated. This cannot be avoided but different extrusion types generate different amounts of heat. There are basically three different types of extruder and the one chosen may have far reaching implications on production operations. It is important that the...