Knowledge Base

Exciting Development for the Future of Oral Dose Drug Delivery

Investigating drug dissolution enhancement and controlled release of solid-liquid hybrid dosage form using Liqui-Pellet technology.

Discover how the Caleva Multi Lab was used to demonstrate the flexibility and potential of Liqui-Pellets as the next generation oral dosage form.

Investigating the Impact of Process Variables in Formulation Development

Discover how Caleva extrusion and spheronization equipment supported a university master’s student in his scientific breakthrough, resulting in his publication in a recognised industry journal.

Shaped Catalyst Body Preparation with MTR and Caleva Screw Extruder

 Shaped Catalyst Body Preparation. Zeolite HZSM-5 (ACS Materials, M38) was mixed as a dry powder with alumina (Sasol, Catapal D (Boehmite)) and the required amount of Milli-Q water to ensure an optimum solid-to-liquid ratio for extrusion (measured using a Mixer Torque Rheometer, Caleva). The paste, containing a ratio of 70:30 wt % zeolite:binder, was extruded using a Mini-Screw Extruder (Caleva),...

Latest Research Paper from University of Karachi

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...

Mini Coater Dryer (air suspension coater) used in formulation development

Tablets were coated with a color overcoat (Aquarius Cool Vanilla BI-1800,Ashland/Aqualon; hydroxypropylmethylcellulose, titanium dioxide, triacetin, polysorbate)using a Caleva air-suspension coater to 2-4% by weight …

Caleva Mixer working in catalyst application for Ethylene and Propylene

Components were mixed with a specialist Caleva mixer to form a homogeneous paste

Mixed solvent system as binder for the production of silicified microcrystalline cellulose‐based pellets

… Then the wet mass was extruded immediately with a radial extruder (Model 20 Extruder, Caleva Ltd, UK) that was fitted with a screen of 150 mm in diameter and 1.0 mm die holes. The extruder screen rotated at 30 rpm. After …

Agglomeration properties of gluten-free flours under water addition and shearing conditions

The different states of agglomeration were identified by the evolution of rheological properties under water addition and shearing conditions using a Caleva®mixer torque rheometer.

Effect of spheronizer plate design on the spheronization of ketoprofen

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation or...

Extrusion–spheronization a promising pelletization technique: In-depth review

Abstract

This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid,excipients, and...

Spheronized Pellets | Extended Release | Poorly Soluble Antiemetic Agent

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...