Caleva Blog

How to produce consistent formulations from different mixers

Customer Quote: Mr. K.S (Aurobindo)

"It is exciting to see the correlation between the two graphs and granulation end point". 

With a major pharmaceutical manufacturer, together we characterised all their various mixers to produce a consistent formulation.

To identify three important characteristics for wet mass materials, namely:

  • The Optimum moisture point
  • The mixing time required to reach...

Caleva's Mixer Torque Rheometer and the Shanghai University of Traditional Chinese Medicine

A short review by:


Ruofei Du | Associate Researcher | Innovation Research Institute of Traditional Chinese Medicine | Shanghai University

"The main research direction of my group is the preparation technology development of Traditional Chinese Medicine.

The Caleva Mixer Torque Rheometer has been widely used in my research, especially in the development of formulations of TCM preparations,...

Do excipients purchased from different vendors behave in the same way?

The Mixer Torque Rheometer can be used to assess the behaviour of excipients purchased from different suppliers.


Excipients from different batches or vendors may be variable in quality and it is often necessary to perform pre-formulation assessment for each batch of excipient received.  In some cases, excipients from different vendors require comparative assessment of their...

Inconsistent spheronization results with difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield (weight of acceptable pellets as a % of weight of granulation made), and dissolution profile....

How reproducible can measurements be of something that is not homogeneous?

The MTR-3 uniquely offers a means of characterising the rheological properties of a wet granulation by providing a quantitative value of the consistency of the material tested. The more traditional hand squeeze test, previously widely used, to measure or compare granulations, is falling into disrepute and is no longer considered appropriate for modern day industrial production or research...

Yield problems in production and quality control

One of the strengths of the Caleva Mixer Torque Rheometer (MTR-3) is that it can be used to verify the properties of wet powder mass samples taken during production in large scale mixer/granulator systems. It can be used simply as a quality control tool on a regular basis or specifically as an aid to problem solving. Small samples can be taken directly from production and within two minutes a...

How the Mixer Torque Rheometer resolved a tablet friability issue

Caleva worked closely with a well known producer of food supplements made from natural materials, plant extracts and other natural food sources.  Their tablet formulations work well and this nutraceutical company has a good reputation for their products.  Generally they do not encounter problems with tablets breaking or disintegrating during manufacture, packing or storage.

Determination of moisture requirement to prepare spheroids by extrusion-spheronization

Spheroids are popularly used in the design of multi-particulate drug delivery systems. Extrusion and spheronization is commonly employed to manufacture spheroids in the pharmaceutical industry. It is a multiple-step manufacturing process which could be summarized into the flow chart as shown in Figure 1.

Save Time and Cost in Formulation Development

In the mid 1990’s, the field of pyrotechnics was limited mainly to applications in aircraft ordnance, fireworks and rock blasting. This has been developed to a highly advanced science and is an extensively used technology which finds application in spacecraft, aircraft and underwater vehicle systems. “Pyrotechnic “is defined as “explosive-actuated” and refers especially to devices in which...

"End Point Determination” Using the Caleva Mixer Torque Rheometer

A company wished to move a formulation currently undergoing product development from small scale laboratory (with batches of 50 grams) to the next stage for a larger scale batch trial of 100 kg (scale–up).  The development had been started using a small Caleva Multi Lab bench top mixer (maximum batch capacity 50 gram of wet mass). This development had been successful and now additional samples...