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Mixer Torque Rheometer used with Food Powders

Research Article University of Padova where their Caleva Rheometer was used

By Andrea Newton
21 Apr 2020 in Mixer Torque Rheometer

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How to produce consistent formulations from different mixers

Customer Quote: Mr. K.S (Aurobindo) "It is exciting to see the correlation between the two graphs and granulation end point".  With a major pharmaceutical manufacturer, together we characterised all their various mixers to produce a consistent formulation. To identify three important characteristics... Read More

Do excipients purchased from different vendors behave in the same way?

The Mixer Torque Rheometer can be used to assess the behaviour of excipients purchased from different suppliers. Background Excipients from different batches or vendors may be variable in quality and it is often necessary to perform pre-formulation assessment for each batch of excipient received.  I... Read More

The Caleva Family of Laboratory Equipment

Whilst you may have heard of Caleva and any one of its flagship pieces of equipment, we'd like to introduce you to the family of Caleva laboratory equipment that you may find helpful for your application in your industry sector.  Choose one process or choose all of them.  Select further functions as... Read More

Inconsistent spheronization results with difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield... Read More

Mixer Torque Rheometer used with Food Powders

Research Article University of Padova where their Caleva Rheometer was used   Abstract Vegetable soups are complex mixtures containing vegetables in different percentages, thickeners, salt, fat, and emulsifying/wetting agents. When prepared as dehydrated powders in convenience foods, they need to be... Read More

The Importance of End Point Detection Consistency

This world is not only for us. Can you imagine world had no animals, what would it be like? Would the trees be green? Without birds or squirrels, less trees would grow. There would be no pets, no flowers and no bees. If even one part of our ecosystem is removed, we will all die. Without animals, we ... Read More

Caleva Multi Lab & Bone Regeneration study Medical University Gdańsk

Drug-loaded mesoporous silica/calcium phosphate composites for bone regeneration Adrian Szewczyk at Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk has kindly allowed us to introduce this paper that introduces a study of Drug-loaded mesoporous silica/calcium phosp... Read More

Agglomeration properties of gluten-free flours under water addition and shearing conditions

The different states of agglomeration were identified by the evolution of rheological properties under water addition and shearing conditions using a Caleva® mixer torque rheometer.  Read More

How reproducible can measurements be of something that is not homogeneous?

The MTR-3 uniquely offers a means of characterising the rheological properties of a wet granulation by providing a quantitative value of the consistency of the material tested. The more traditional hand squeeze test, previously widely used, to measure or compare granulations, is falling into disrepu... Read More

Yield problems in production and quality control

One of the strengths of the Caleva Mixer Torque Rheometer (MTR-3) is that it can be used to verify the properties of wet powder mass samples taken during production in large scale mixer/granulator systems. It can be used simply as a quality control tool on a regular basis or specifically as an aid t... Read More

How the Mixer Torque Rheometer resolved a tablet friability issue

Caleva worked closely with a well known producer of food supplements made from natural materials, plant extracts and other natural food sources.  Their tablet formulations work well and this nutraceutical company has a good reputation for their products.  Generally they do not encounter problems wit... Read More

Determination of moisture requirement to prepare spheroids by extrusion-spheronization

Spheroids are popularly used in the design of multi-particulate drug delivery systems. Extrusion and spheronization is commonly employed to manufacture spheroids in the pharmaceutical industry. It is a multiple-step manufacturing process which could be summarized into the flow chart as shown in Figu... Read More

Save Time and Cost in Formulation Development

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"End Point Determination” Using the Caleva Mixer Torque Rheometer

A company wished to move a formulation currently undergoing product development from small scale laboratory (with batches of 50 grams) to the next stage for a larger scale batch trial of 100 kg (scale–up).  The development had been started using a small Caleva Multi Lab bench top mixer (maximum batc... Read More

Caleva Mixer Torque Rheometer - The importance of mixing time for your formulation development and production

It is well established and understood that one of the most important factors in the development of a formulation for both tableting and making pellets by extrusion and spheronization is the amount of liquid binder added to the formulation. What is less widely acknowledged is the importance of mixing... Read More