A list of suggested uses for pellets in pharmaceutical applications.
We are working closely with many partners in a wide variety of industries as well as pharmaceutical. The industries where we are helping our customers to make pellets and extrudates are listed below.
Extrusion and spheronization is not always completely straightforward. A formulation required for spheronization needs to go through the following processes and achieve the following properties.
Wet Granulation - Granules are formed by the addition of a granulation liquid onto a bed of powder under the influence of an impeller. This is typically carried out using a high-shear granulator or a simpler planetary mixer.
There are two main ways to make small pellets for drug delivery:
There is no right or wrong way to make pellets. The most appropriate method for your particular application will depend on what you are trying to...
We always offer our potential users the opportunity to test their formulation with us in our lab. This is to ensure that installing our machines would be the right decision for their formulation development, and/or their production environment.
This short article has been written from notes that Dr Steve Robinson made during trials with catalysts sent to us by a customer and we achieved some...
Product yields (the percentage of the spheroids produced in a batch that are within the size range required) will never be 100%.
We recently had a visitor from Asia who was trying to solve a problem with their cosmetic formulation. The investigator wished to have approximately 1 mm diameter pellets. The formulation presented was a tough, waxy material in irregular broken blocks that were up to about 10 mm in diameter and was unable to be spheronized into the required size or shape.
In some circumstances it is possible to omit the extrusion stage, but the results may not be what you need.
It is dependent on what you need to achieve with your result and what you want to do in the next phase of the project. Whether or not you decide to include the extrusion stage will depend on what you want to achieve with your project.
In many cases the main reason for the use of pellets in the manufacture of products is for its controlled release properties. However there are reasons to believe that pellets or spheroids in any case can offer a superior therapeutic effect even when modified release is not the prime objective.
Spheronization, marumerization, pelletization and micropelletization all mean the same thing. The manufacture of products in small spheres (spheroids) for use in pharmaceutical (pharma) and catalyst industries. Within each batch the spheroids are of regular shape and size and are quite dense. The products produced by these processes can be called spheroids, spheres, micro-spheres, pellets,...
The extruder attachment on the Caleva CML does not have a water jacket. Does it need one?
All extruders generate heat and screw extruders generate more than most other extruder types. For this reason, water jackets are generally an integral part of single or twin-screw extruders.
We are often asked for advice by researchers and teachers who want to acquire laboratory equipment for the development of both formulations and processes using the techniques of Extrusion and Spheronization in the laboratory. All users are individual and have different requirements and there is not a single system that will fit all needs.
Find out what you need to consider.
The Caleva Multi-Lab (CML) is capable of performing 3 different processes: Mixing, Extrusion and Spheronization.
This article is about the mixing and granulation phase of the process.
The multi-lab works with a large range of materials from pharmaceutical materials and catalysts, to agricultural products.
The mixer attachment blades thoroughly mix the liquid binder with the...
The Caleva Multi-Lab (CML) is often considered to be the flagship of Caleva lab equipment.
Being able to perform 3 different processes rapidly in one machine with a footprint just slightly larger than an A3 piece of paper, makes the CML a welcome addition to any lab space that...
Whilst you may have heard of Caleva and any one of its flagship pieces of equipment, we'd like to introduce you to the family of Caleva laboratory equipment that you may find helpful for your application in your industry sector. Choose one process or choose all of them. Select further functions as you need them. This adaptable and future proof suite of equipment will allow you to obtain proof...
Adrian Szewczyk at Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk has kindly allowed us to introduce this paper that introduces a study of Drug-loaded mesoporous silica/calcium phosphate composites for bone regeneration.
Components were mixed with a specialist Caleva mixer to form a homogeneous paste
Over the past couple of years I have worked with a huge number of chemical engineering teams, trying to crack the optimum base for a catalyst pellet. After hours of trials and research, I am pleased to say, we’ve done it!
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