In many cases the main reason for the use of pellets in the manufacture of products is for its controlled release properties. However there are reasons to believe that pellets or spheroids in any case can offer a superior therapeutic effect even when modified release is not the prime objective.
Spheronization, marumerization, pelletization and micropelletization all mean the same thing. The manufacture of products in small spheres (spheroids) for use in pharmaceutical (pharma) and catalyst industries. Within each batch the spheroids are of regular shape and size and are quite dense. The products produced by these processes can be called spheroids, spheres, micro-spheres, pellets,...
The extruder attachment on the Caleva CML does not have a water jacket. Does it need one?
All extruders generate heat and screw extruders generate more than most other extruder types. For this reason, water jackets are generally an integral part of single or twin-screw extruders.
- Given the small batch sizes (10 to 100 g) that are optimum for the CML extruder, a well formulated extrudate will...
We are often asked for advice by researchers and teachers who want to acquire laboratory equipment for the development of both formulations and processes using the techniques of Extrusion and Spheronization in the laboratory. All users are individual and have different requirements and there is not a single system that will fit all needs.
Find out what you need to consider.
The Caleva Multi-Lab (CML) is capable of performing 3 different processes: Mixing, Extrusion and Spheronization.
This article is about the mixing and granulation phase of the process.
The multi-lab works with a large range of materials from pharmaceutical materials and catalysts, to agricultural products.
The mixer attachment blades thoroughly mix the liquid binder with...
Call Caleva's friendly team to talk about this unique solution for your applications, whatever your challenges are.
The Caleva Multi-Lab (CML) is often considered to be the flagship of Caleva lab equipment.
Being able to perform 3 different processes rapidly in one machine with a footprint just slightly larger than an A3 piece of paper, makes the CML a welcome addition to any lab space that...
Whilst you may have heard of Caleva and any one of its flagship pieces of equipment, we'd like to introduce you to the family of Caleva laboratory equipment that you may find helpful for your application in your industry sector. Choose one process or choose all of them. Select further functions as you need them. This adaptable and future proof suite of equipment will allow you to obtain...
Drug-loaded mesoporous silica/calcium phosphate composites for bone regeneration
Adrian Szewczyk at Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk has kindly allowed us to introduce this paper that introduces a study of Drug-loaded mesoporous silica/calcium phosphate composites for bone regeneration.
Components were mixed with a specialist Caleva mixer to form a homogeneous paste
How can I be sure that the trials and development work that I do will give me comparable results when I need to scale up to production sizes?
- The smallest extruder we offer is the Caleva Multi Lab (CML) with an extruder attachment designed to work with...
Over the past couple of years I have worked with a huge number of chemical engineering teams, trying to crack the optimum base for a catalyst pellet. After hours of trials and research, I am pleased to say, we’ve done it!
Caleva Mixer Torque Rheometer - The importance of mixing time for your formulation development and production
It is well established and understood that one of the most important factors in the development of a formulation for both tableting and making pellets by extrusion and spheronization is the amount of liquid binder added to the formulation. What is less widely acknowledged is the importance of mixing and the mixing regime used. The concept of “granulation end point” is recognised but there is...
Update: Now shipping as fast as we can make them!