Caleva Blog

Mixing trials with a Caleva Mixer Granulator and difficult materials

Two different products were tested to help a customer who was finding some difficulty in obtaining homogeneous mixes of small volumes. These materials were considered difficult to mix to a homogeneous state in the batch sizes required.

PRODUCT 1, TRIAL 1

A mix of sugar and salt in the ratio of 2:1
A batch of 100 grams of household sugar was weighed and added to the mixing bowl, together with a...
CML, VDE

How do I decide which laboratory extruder and spheronizer I need?

We are often asked for advice by researchers and teachers who want to acquire laboratory equipment for the development of both formulations and processes using the techniques of Extrusion and Spheronization in the laboratory.  All users are individual and have different requirements and there is not a single system that will fit all needs.

Find out what you need to consider.

 

How to produce consistent formulations from different mixers

Customer Quote: Mr. K.S (Aurobindo)

"It is exciting to see the correlation between the two graphs and granulation end point". 

With a major pharmaceutical manufacturer, together we characterised all their various mixers to produce a consistent formulation.

To identify three important characteristics for wet mass materials, namely:

  • The Optimum moisture point
  • The mixing time required to reach...

Extrusion of small batches

The Caleva Multi-Lab (CML) can Mix/Granulate, Extrude and Spheronize all in one base unit.

This article is about the Extruder attachment that comes with the CML.

The Multi-lab is capable of working with a variety of materials from catalysts and pharmaceuticals, to agricultural products.

The Extruder

The extrusion attachment on the CML is in the form of a single screw Extruder. A variety of...

Mixing and granulating small batches

The Caleva Multi-Lab (CML) is capable of performing 3 different processes: Mixing, Extrusion and Spheronization.

This article is about the mixing and granulation phase of the process.

The multi-lab works with a large range of materials from pharmaceutical materials and catalysts, to agricultural products.

The granulator/mixer

The mixer attachment blades thoroughly mix the liquid binder with...

Mix, Extrude & Spheronize in a single base - watch a video

Call Caleva's friendly team to talk about this unique solution for your applications, whatever your challenges are.

 

The Caleva Multi-Lab (CML) is often considered to be the flagship of Caleva lab equipment.

Being able to perform 3 different processes rapidly in one machine with a footprint just slightly larger than an A3 piece of paper, makes the CML a welcome addition to any lab space that...

Caleva's Mixer Torque Rheometer and the Shanghai University of Traditional Chinese Medicine

A short review by:

 

Ruofei Du | Associate Researcher | Innovation Research Institute of Traditional Chinese Medicine | Shanghai University

"The main research direction of my group is the preparation technology development of Traditional Chinese Medicine.

The Caleva Mixer Torque Rheometer has been widely used in my research, especially in the development of formulations of TCM preparations,...

How do I coat tablets or pellets with the Caleva Mini Coater Drier

The Mini Coater Drier (MCD) is an incredibly useful piece of equipment when it comes to coating and drying small batches of tablets or pellets. For a demonstration of the MCD in use, you can watch the video on this page, or for some quick pieces of information on the MCD, check the bullet points below.

  • From a single tablet up to about 150 tablets
  • From a few grams to about 60 grams of small...

See the Caleva Multi Lab at AC Compacting in New Jersey

Why not contact AC Compacting with a view to seeing and trying the Multi Lab on their site in New Jersey.  Richard, Paul and the team are there to welcome you.

  • Reduce bench-space requirement
  • Improve development speed by reducing the time needed for your trials
  • Investigate more parameters, more options with Variable Density Extrusion
  • Save money in materials, equipment and by increased...

The very small footprint Caleva Multi Lab

 

Mix/granulate, extrude & spheronize all in a single base unit just slightly larger than an A3 piece of paper

Do excipients purchased from different vendors behave in the same way?

The Mixer Torque Rheometer can be used to assess the behaviour of excipients purchased from different suppliers.

Background

Excipients from different batches or vendors may be variable in quality and it is often necessary to perform pre-formulation assessment for each batch of excipient received.  In some cases, excipients from different vendors require comparative assessment of their...

The Caleva Family of Laboratory Equipment

Whilst you may have heard of Caleva and any one of its flagship pieces of equipment, we'd like to introduce you to the family of Caleva laboratory equipment that you may find helpful for your application in your industry sector.  Choose one process or choose all of them.  Select further functions as you need them.  This adaptable and future proof suite of equipment will allow you to obtain...

Major European Chemistry & Catalysis Department uses Caleva Multi Lab in new catalyst formulations to gain greater thermal stability

Why is platinum and palladium in automotive catalyst formulations?

Which extrusion die do I need?

How do I select the right extruder die to get the size of pellets that I need?   There is no simple answer to this question as it depends on the characteristics of your formulation and the size of the pellets you require.

One of the key factors (but not the only factor) that determines the diameter of the final dry pellet is the diameter of the hole in the extruder die. For example, if you are...

Caleva online training for existing and new users of its equipment

 

 

 

 

 

 

 

If extrusion and spheronization is new to you then the learning can be accelerated if training is provided by experienced staff from Caleva Process Solutions. Caleva will always support its customers wherever possible. Due to the level of cost of some of the laboratory items that we supply it is not always possible to go visit customers in person and offer training at their...

PharmaTeG purchase a Caleva Mixer Torque Rheometer MTR3

 

PharmaTeG – Pharmaceutical Technology Group - is founded by a group of pharmaceutical technologists belonging to the Department of Pharmaceutical and Pharmacological Science and School of Hospital Pharmacy, University of Padova, Italy. The group collaborates with the Industrial Engineering Department of the University of Padova (APTLab – Advanced Particle Technology Laboratory) with whom it...

Can power use in granulation predict tablet dissolution & hardness?

The recent research paper from Tomoto Otsuka et al (Chem. Pharm. Bull. 66, 554-561 2018) have shown that high shear granulation processes can influence final product properties such as tablet dissolution and hardness.The question raised by this paper was related to useful methods of evaluating the “kneading state” of a wet mass obtained during the granulation process. The most commonly used...

Inconsistent spheronization results with difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield (weight of acceptable pellets as a % of weight of granulation made), and dissolution profile....

Mixer Torque Rheometer used with Food Powders

Research Article University of Padova where their Caleva Rheometer was used

Caleva and A C Compacting attend Installation at Impax Taiwan

Caleva's leading designer, Mr Michael Silvey recently attended preliminary installations at Impax Laboratories Inc in Taiwan. Michael worked alongside Impax engineers and A C Compacting LLC, Mr Larry Malchuk, to set up the installation of the 2nd (in a series of several) Caleva 700 Twin Spheronizers that Impax are installing at their facility in Taiwan, having previously undertaken a projects...