Caleva Blog

Do excipients purchased from different vendors behave in the same way?

The Mixer Torque Rheometer can be used to assess the behaviour of excipients purchased from different suppliers.

Background

Excipients from different batches or vendors may be variable in quality and it is often necessary to perform pre-formulation assessment for each batch of excipient received.  In some cases, excipients from different vendors require comparative assessment of their...

The Caleva Family of Laboratory Equipment

Whilst you may have heard of Caleva and any one of its flagship pieces of equipment, we'd like to introduce you to the family of Caleva laboratory equipment that you may find helpful for your application in your industry sector.  Choose one process or choose all of them.  Select further functions as you need them.  This adaptable and future proof suite of equipment will allow you to obtain...

Major European Chemistry & Catalysis Department uses Caleva Multi Lab in new catalyst formulations to gain greater thermal stability

Why is platinum and palladium in automotive catalyst formulations?

Which extrusion die do I need?

How do I select the right extruder die to get the size of pellets that I need?   There is no simple answer to this question as it depends on the characteristics of your formulation and the size of the pellets you require.

One of the key factors (but not the only factor) that determines the diameter of the final dry pellet is the diameter of the hole in the extruder die. For example, if you are...

Caleva online training for existing and new users of its equipment

 

 

 

 

 

 

 

If extrusion and spheronization is new to you then the learning can be accelerated if training is provided by experienced staff from Caleva Process Solutions. Caleva will always support its customers wherever possible. Due to the level of cost of some of the laboratory items that we supply it is not always possible to go visit customers in person and offer training at their...

PharmaTeG purchase a Caleva Mixer Torque Rheometer MTR3

 

PharmaTeG – Pharmaceutical Technology Group - is founded by a group of pharmaceutical technologists belonging to the Department of Pharmaceutical and Pharmacological Science and School of Hospital Pharmacy, University of Padova, Italy. The group collaborates with the Industrial Engineering Department of the University of Padova (APTLab – Advanced Particle Technology Laboratory) with whom it...

Can power use in granulation predict tablet dissolution & hardness?

The recent research paper from Tomoto Otsuka et al (Chem. Pharm. Bull. 66, 554-561 2018) have shown that high shear granulation processes can influence final product properties such as tablet dissolution and hardness.The question raised by this paper was related to useful methods of evaluating the “kneading state” of a wet mass obtained during the granulation process. The most commonly used...

Inconsistent spheronization results with difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield (weight of acceptable pellets as a % of weight of granulation made), and dissolution profile....

Mixer Torque Rheometer used with Food Powders

Research Article University of Padova where their Caleva Rheometer was used

Caleva and A C Compacting attend Installation at Impax Taiwan

Caleva's leading designer, Mr Michael Silvey recently attended preliminary installations at Impax Laboratories Inc in Taiwan. Michael worked alongside Impax engineers and A C Compacting LLC, Mr Larry Malchuk, to set up the installation of the 2nd (in a series of several) Caleva 700 Twin Spheronizers that Impax are installing at their facility in Taiwan, having previously undertaken a projects...

Caleva new installation at La Plata University, Argentina

The University of La Plata in Argentina** is one of the most important (and largest) universities in Argentina. It is situated in La Plata that is the capital of the province Buenos Aires.

A visitor to Caleva uses innovative Caleva technology to help investigations into the control of leaf cutting ants in Costa Rica

Ms Catherine Jimenez from the Laboratorio do Biotechnologia, Universidad de Costa Rica is working in collaboration with a company to produce a novel ant bait for use against a major agricultural pest.

The requirements for the study was to have available a laboratory extruder that would be able to produce extrudate not only of different diameters but also of different densities. Using a...

Matthias Setzepfand, Director del Grupo MSE-Processing Equipments

Más informaciones sobre nosotros encuentras en nuestra página web. http://www.mseprocessing.com/ o mucho más detallado en la página web de Caleva /

University of La Plata Argentina, Dr Arturo Hoya, develops low cost essential medicines with equipment Caleva equipment

 

Caleva flagship equipment at Instituto Polo Tecnológico Uruguay

Dr Steve Robinson worked with the team at the Laboratorio de Biotecnología to install a Caleva Multi Lab and Mini Coater Drier.

Installation training was completed over a period of two days. The first day was dedicated to the processes of granulation, extrusion and spheronization using the Multi Lab and the following day the pellets created on the previous day were coated and dried.

Caleva training seeks both successful and unsuccessful results - why?

Installation and training is generally specifically designed so that the operators and users can learn how to use the equipment and quickly learn  through a series of procedures to produce acceptable results. However, our experience after several years of working with operators and researchers during installation and training, tells us that users learn more about the equipment and the...

Caleva visit to Sandoz for an MTR install

Last week, Scott and Steve represented Caleva, by travelling to India to meet Our long standing distributor for the region, GDI. With Hirak and Prasanta from GDI, they attended meetings, gave presentations and performed an installation and training session of the MTR-3 for Sandoz, a company which is a branch of Novartis and recently purchased the equipment for their research and development...

The Importance of End Point Detection Consistency

This world is not only for us. Can you imagine world had no animals, what would it be like? Would the trees be green? Without birds or squirrels, less trees would grow. There would be no pets, no flowers and no bees. If even one part of our ecosystem is removed, we will all die. Without animals, we will surely go extinct.

What do ATI and Caleva offer in Vietnam?

Hãng Calveva có bề dày kinh nghiệm trên 50 năm thiết kế và sản xuất thiết bị bào chế thuốc dạng cốm, Pellets, spheroids. Hệ thiết bị của hãng đáp ứng tiêu chuẩn cao về dược phẩm và an toàn thực phẩm như GMP, GLP,GPP..thiết bị bao gồm toàn diện từ khâu trộn, đùn , vo hạt và bao hạt Pellet, cụ thể như sau:

Coating of very small capsules with the Caleva Mini Coater Drier

The Caleva small tablet and pellet coater is well known for the coating and drying of very small batches of pellets and tablets. It is the only commercially available equipment for this task. It will coat from a single tablet or a few grams of pharmaceutical (or related) pellets. The process was developed for pharmaceutical pellet applications, but is also suitable for other applications (such...