Knowledge Base

The process of spheronization consists of four key steps:-

• To optimize and achieve the right binder addition  & mixing time for your formulation
• Mixing or granulation - a mixer or granulator is required
• Extrusion - an extruder is required
• Spheronization - a spheronizer is required
• Drying and possibly coating - a coater and drier may be required

This is all made simple by the Caleva suite of R&D...

 Shaped Catalyst Body Preparation. Zeolite HZSM-5 (ACS Materials, M38) was mixed as a dry powder with alumina (Sasol, Catapal D (Boehmite)) and the required amount of Milli-Q water to ensure an optimum solid-to-liquid ratio for extrusion (measured using a Mixer Torque Rheometer, Caleva). The paste, containing a ratio of 70:30 wt % zeolite:binder, was extruded using a Mini-Screw Extruder (Caleva),...

Call Caleva's friendly team to talk about this unique solution for your applications, whatever your challenges are.

The Caleva Multi-Lab (CML) is often considered to be the flagship of Caleva lab equipment.

Being able to perform 3 different processes rapidly in one machine with a footprint just slightly larger than an A3 piece of paper, makes the CML a welcome addition to any lab space that...

The small size of the CML is just one of the many advantages that this piece of equipment can offer. Having the ability to complete 3 processes in one machine, whilst also taking up a minimal amount of bench top space, makes the CML a great addition to any lab space that works with the processes of mixing/granulation, extrusion and spheronization.

Whilst you may have heard of Caleva and any one of its flagship pieces of equipment, we'd like to introduce you to the family of Caleva laboratory equipment that you may find helpful for your application in your industry sector. Choose one process or choose all of them. Select further functions as you need them. This adaptable and future proof suite of equipment will allow you to obtain proof of...

Tablets were coated with a color overcoat (Aquarius Cool Vanilla BI-1800,Ashland/Aqualon; hydroxypropylmethylcellulose, titanium dioxide, triacetin, polysorbate)using a Caleva air-suspension coater to 2-4% by weight …

Components were mixed with a specialist Caleva mixer to form a homogeneous paste

… Then the wet mass was extruded immediately with a radial extruder (Model 20 Extruder, Caleva Ltd, UK) that was fitted with a screen of 150 mm in diameter and 1.0 mm die holes. The extruder screen rotated at 30 rpm. After …

The different states of agglomeration were identified by the evolution of rheological properties under water addition and shearing conditions using a Caleva^®mixer torque rheometer.

Many experts recognise Caleva as a leading manufacturer in extrusion and spheronization equipment for the development of pharmaceutical formulations, catalysts and ceramics. However, the broard scope and flexibility of Caleva equipment provides diverse capabilities that is leading to emerging applications in implant manufacture and conservation science. To explain more, we caught up with Dr Anton...

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation or...

Over the past couple of years I have worked with a huge number of chemical engineering teams, trying to crack the optimum base for a catalyst pellet. After hours of trials and research, I am pleased to say, we’ve done it!

OK, so this was a tip I discovered a while back, but now it’s becoming more and more beneficial for me in practice when working with sticky, viscous materials.  Perhaps this will help you too?