The Caleva variable Density Kit will allow you to develop pellets with different densities, thus widenening your chance of achieving a successful formulation. The kit is made up of the Caleva Variable Density Extruder and the Multi Bowl benchtop spheronizer with a 250 mm diameter bowl attached.
Caleva Model VDE benchtop Variable Density Extruder is designed to offer you the ability to produce experimental formulation applications with different densities. It is a novel extruder design and utilises a variety of screen screen thicknessesin the axial configuration from 1mm to 12mm. The extruder holes for example for any diameter extrudate can be between 1 and 12 mm in length.
The Density of the extrudate of any given diameter varies as a function of the extruder screen hole length thus the name of the Variable Density Extruder. So by changing a screen hole depth you can increase the density of the extrudate. This can offer several advantages depending on the end use of the product.
The extrudate quality improves dramatically as the hole length and therefore density increases exhibiting smoother surfaces with less breaks and voids. If this extrudate is used for spheronization this then can lead to spheres that are very consistent in both their “roundness” and size distribution which usually results in higher usable yields.
The Caleva MBS (Multi Bowl Spheronizer) is the most complete bench-top spheronizer available as a standard configuration. With its optional bowls it is a cost effective way of working with a wide range of batch sizes in a single machine. Optional interchangeable bowls allow spheronization of batch sizes from 1 gram to 1000 gram. The standard bowl is suitable for batch sizes from 100 gram to 1500 gram; (usable capacity up to about 1.6 litres of standard pharmaceutical product).
Caleva offer equipment and development support for full-scale production as well as bench-top equipment for formulation development and trial work. All of our laboratory equipment is designed to facilitate fast, and trouble free, scale-up to production.