Mixing & Granulation
High shear granulation equipment for Mixing and granulation
Extrusion
Equipment that can extrude as little as 10g of material, all the way up to 150kg per hour
Spheronization
From lab scale spheronization equipment up to full production size. Making scale up easy and consistent
Coating/drying tablets and pellets
Coat from a single tablet up to 150 tablets in a single batch
Rheology of wet masses
Quantify the characteristics of your wet mass to correctly determine the end point of your granulation
Mix small samples on this benchtop machine.
Proven ability to mix, blend, de-agglomerate and granulate a wide range of different materials in small batches.
Demonstrated efficacy with powder batch sizes from about 10 g to 50 g depending on the bulk density of the sample
Liquids, creams and fluids have been demonstrated to be blended with batch sizes ranging from 20 ml to 170 ml
The CML possesses all of the same abilities as the MGB listed above, but has the added benefits of being able to extrude and spheronize your product.
Works with batch sizes from 10 to 50 g
Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.
Turn powder into pellets in under 15 minutes.
The CML is capable of 3 processes, mixing, extrusion and spheronization.
It has a remarkably small "footprint" just larger than a sheet of A3 paper
Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.
Turn powder into pellets in under 15 minutes.
Multiple die hole diameter and depth options for ultimate control over your extrudate properties, whilst also allowing you to explore variable density
Suitable for a wide variety of industries including pharmaceuticals, ceramics, catalysts and others.
Water jacket option for warming or cooling available
Low pressure screen extrusion system designed for easy scale up
Suitable for food, pharmaceutical, nutraceutical or other similar applications
Has the option of interchangeable screens, different die hole sizes and variable screen heights.
The perfect scale up option from the E20
Easy to clean
Works with a range of industries such as pharmaceutical, catalyst manufacture, petrochemicals and ceramics
Designed for continuous or intermittent production within industrial environments.
The twin-screw design provides a consistent and effective extrusion action
The CML is capable of 3 processes, Mixing, extrusion and spheronization.
Multiple different disk patterns are available to increase your chances of formulation development success.
Turn powder into pellets in under 15 minutes.
Designed for ease of scale-up to cost effective manufacture
4 bowl sizes available, so that you can work with the widest possible range of batch sizes
Produces high quality results in a range of industries from animal feed and pharmaceutical products to ceramics and more.
Quick and easy disassembly for cleaning, allowing for quick turn around to keep your production process flowing smoothly
Has a relatively small "footprint" making it easy to store and easy to fit into smaller areas
Multiple disk patterns are available, including dust reducing radial designs
Lockable wheels on it's base for easy movement and positioning.
Designed for continuous or intermittent production within industrial environments.
Air blast cleaning technology to enhance efficiency during continuous operation
Batch operation with fully automatic discharge
Achieve excellent uniformity in your batches whilst reducing your product cost.
Overcome limited product availability by coating extremely small amounts of product
Produce results quickly, easily and efficiently
The MTR allows you to save time and money in your formulation development
The only repeatable and reliable way to quantify your wet mass to correctly determine the end point of your granulation
Learn how your formulations can be affected by under or over mixing
Mixing & Granulation
High shear granulation equipment for Mixing and granulation
Mix small samples on this benchtop machine.
Proven ability to mix, blend, de-agglomerate and granulate a wide range of different materials in small batches.
Demonstrated efficacy with powder batch sizes from about 10 g to 50 g depending on the bulk density of the sample
Liquids, creams and fluids have been demonstrated to be blended with batch sizes ranging from 20 ml to 170 ml
The CML possesses all of the same abilities as the MGB listed above, but has the added benefits of being able to extrude and spheronize your product.
Works with batch sizes from 10 to 50 g
Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.
Turn powder into pellets in under 15 minutes.
Extrusion
Equipment that can extrude as little as 10g of material, all the way up to 150kg per hour
The CML is capable of 3 processes, mixing, extrusion and spheronization.
It has a remarkably small "footprint" just larger than a sheet of A3 paper
Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.
Turn powder into pellets in under 15 minutes.
Multiple die hole diameter and depth options for ultimate control over your extrudate properties, whilst also allowing you to explore variable density
Suitable for a wide variety of industries including pharmaceuticals, ceramics, catalysts and others.
Water jacket option for warming or cooling available
Low pressure screen extrusion system designed for easy scale up
Suitable for food, pharmaceutical, nutraceutical or other similar applications
Has the option of interchangeable screens, different die hole sizes and variable screen heights.
The perfect scale up option from the E20
Easy to clean
Works with a range of industries such as pharmaceutical, catalyst manufacture, petrochemicals and ceramics
Designed for continuous or intermittent production within industrial environments.
The twin-screw design provides a consistent and effective extrusion action
Spheronization
From lab scale spheronization equipment up to full production size. Making scale up easy and consistent
The CML is capable of 3 processes, Mixing, extrusion and spheronization.
Multiple different disk patterns are available to increase your chances of formulation development success.
Turn powder into pellets in under 15 minutes.
Designed for ease of scale-up to cost effective manufacture
4 bowl sizes available, so that you can work with the widest possible range of batch sizes
Produces high quality results in a range of industries from animal feed and pharmaceutical products to ceramics and more.
Quick and easy disassembly for cleaning, allowing for quick turn around to keep your production process flowing smoothly
Has a relatively small "footprint" making it easy to store and easy to fit into smaller areas
Multiple disk patterns are available, including dust reducing radial designs
Lockable wheels on it's base for easy movement and positioning.
Designed for continuous or intermittent production within industrial environments.
Air blast cleaning technology to enhance efficiency during continuous operation
Batch operation with fully automatic discharge
Coating/drying tablets and pellets
Coat from a single tablet up to 150 tablets in a single batch
Achieve excellent uniformity in your batches whilst reducing your product cost.
Overcome limited product availability by coating extremely small amounts of product
Produce results quickly, easily and efficiently
Rheology of wet masses
Quantify the characteristics of your wet mass to correctly determine the end point of your granulation
The MTR allows you to save time and money in your formulation development
The only repeatable and reliable way to quantify your wet mass to correctly determine the end point of your granulation
Learn how your formulations can be affected by under or over mixing
If so, please click the image below to see how to arrange your demonstration.
Spheronization is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.
The products produced from this process can be useful in several ways
Product performance and functionality can be improved or changed to meet a wide range of requirements
Plant procedures can be simplified, to reduce costs or enhance security of operation
The process is well known and widely used in the pharmaceutical, nutraceutical, catalyst, petrochemical, materials science and other industries. Its use is becoming increasingly recognized in other areas of industrial material handling.
[The] Caleva Multi Lab was an important instrument during the initial development of Liqui-Pellet technology, an emerging next generation oral dosage form. The machine has multifunction such as mixing, extruding and spheronizing in a single package that is simple to operate. Although there are different types of approaches in extruding, the extruder in the Caleva Multi Lab is excellent as it works well with the spheroniser to produce uniform size pellets. This is due to the well designed friction plate and capability to adjust the spheronizing speed, which can be set to be very fast. I find not all pelletizers offer such high speed of spheronization.
Dr Matthew Lam London Metropolitan University
The University of South Australia purchased the Extruder 20, the Multi Bowl Spheronizer; and the Mini coater/drier from Caleva in 2013 and 2019, respectively. These pieces of equipment have greatly assisted us with our research activities. Their operating systems are user-friendly, owing to the many parameters that can be easily optimized for the different formulations. In addition to this, an efficient cleaning and maintaining procedure are easy to perform.
Dr May Song University of South Australia
I have found using Caleva’s Mixer Torque Rheometer (MTR) and the Multi-Lab (granulator, extruder and spheronizer) most valuable in my research where I am reformulating existing active pharmaceutical ingredients into smarter formulations capable of minimising the associated pill burden among patients taking multiple medication as well as improving access to essential medicines.
Dr Francis Brako The Medway School of Pharmacy
When transferring a new technology from R&D into production, process flexibility and equipment adaptability are key. Caleva was a true partner, working with us to find a creative solution to a difficult engineering problem.
Erik Koep Chief Executive Officer at Worn Again
We really appreciated your continual input throughout the qualification process and also your recommendations on how to obtain the best possible results from the machines for our future batches.
Shayeba Khan Renata Limited
The [Caleva Multi Lab] machine is very convenient, well designed, and helped my research a lot.
Bakzhan Yergali Nazarbayev University
The system works well and is in particular attractive for us due to its ability to work with extremely small numbers of tablets. We are very satisfied.
Dr Gerhard Winter LMU Munich
We were very pleased with the quality of service that Caleva provided. We sincerely appreciate their attentiveness and the way they conduct their business.
David Haroun Labise
Caleva provided very helpful advice before we finally purchased their equipment. We found their after sales advice very great too.
Ioannis Yannikos Aristotle University
We are very happy with the 2 sets of extruders/spheronizers and appreciate the excellent assistance from the whole Caleva staff.
DIFFUCAP-CHEMOBRAS Quimica e Farmaceutica Ltda
Following a training session provided by Caleva, our experienced PhD student rapidly got to grips with the equipment and found it straightforward
Dr Alexander Edwards University of Reading
The Caleva Powder Extrusion Suite is an invaluable resource to the research at the Bernal Institute, particularly in the activities of the Pharmaceutical Manufacturing Technology Centre (PMTC)
Prof. Gavin Walker University of Limerick
Caleva were extremely nice and knowledgeable through presenting new technology and reliable products that achieve our client’s needs and satisfaction.
Qusay Kareem Knowledge House Engineering Supplies
We have bought Caleva Extruder, Spheronizer and coater systems in Summer 2015. We had a very good training about the instrument by Caleva. They were really flexible.
Ali Nokhodchi University of Sussex
I used the Caleva Model 20 extruder and Caleva MBS 250 spheronizer to develop a multiparticulate prednisone dosage form during my master’s studies at Rhodes University. The instrument was highly efficient and produced spherical pellets with high drug load. Furthermore, the simplified design allowed ease of operation.
Arthur Manda Rhodes University
The Caleva equipment has been very straightforward to set-up and operate. I was able produce suitable spheres on my second attempt, having barely referenced the instruction manuals. [The Mini Coater Dryer] is hugely adjustable and allows the operator a great degree of scope in accommodating almost any kind of coating that might be applied as a liquid, to a solid dose form. All machines are engineered and built to very high standards.
Senior Chemist Kiwicare
Cert No. 1503
ISO 9001