Laboratory Equipment for Formulation Development

The MLS has arrived last week and we have since worked through the user manuals and made the first two batches [of pellets/beads]. Everything works seamlessly and we are looking forward to fully incorporating the MLS into our research over the next weeks. The quality of the first batches was great and we are positively surprised by the ease of use and time saved making the beads.

Tristan Spreng Imperial College London

We express our sincere appreciation to Caleva for providing us with the essential Mixer Torque Rheometer (MTR), a critical component in our wet granulation formulation studies at Nobel İlaç. The support and equipment supplied by Caleva have been instrumental in our research endeavors. We appreciate the opportunities this technology has presented, allowing us to conduct in-depth analyses of our formulations for tablets, extrudate, and pellets. We excite about the prospects of advancing our research with the MTR. Thank you for your support and we are eager to further explore the possibilities ahead.

Sinem Yetim Pharmaceutical R&D Specialist and Mentor at Nobel İlaç, Türkiye

Using the CML and MTR in combination we’re learning a lot about our catalyst material. The machines are easy to use, and we have achieved very accurate measurements, giving us precise repeatability. The MTR has been a massive advantage in our research and we’re doing things with the material we didn’t think were possible. The speed and ease of use have allowed us to conduct numerous experiments in a single day - we’ve accumulated vast amounts of data to inform our scale up. Both the CML and MTR are manufactured to a very high standard and are very dependable.

IGTL Technology LTD

[The] Caleva Multi Lab was an important instrument during the initial development of Liqui-Pellet technology, an emerging next generation oral dosage form. The machine has multifunction such as mixing, extruding and spheronizing in a single package that is simple to operate. Although there are different types of approaches in extruding, the extruder in the Caleva Multi Lab is excellent as it works well with the spheroniser to produce uniform size pellets. This is due to the well designed friction plate and capability to adjust the spheronizing speed, which can be set to be very fast. I find not all pelletizers offer such high speed of spheronization.

Dr Matthew Lam London Metropolitan University

The University of South Australia purchased the Extruder 20, the Multi Bowl Spheronizer; and the Mini coater/drier from Caleva in 2013 and 2019, respectively. These pieces of equipment have greatly assisted us with our research activities. Their operating systems are user-friendly, owing to the many parameters that can be easily optimized for the different formulations. In addition to this, an efficient cleaning and maintaining procedure are easy to perform.

Dr May Song University of South Australia

I have found using Caleva’s Mixer Torque Rheometer (MTR) and the Multi-Lab (granulator, extruder and spheronizer) most valuable in my research where I am reformulating existing active pharmaceutical ingredients into smarter formulations capable of minimising the associated pill burden among patients taking multiple medication as well as improving access to essential medicines.

Dr Francis Brako The Medway School of Pharmacy

When transferring a new technology from R&D into production, process flexibility and equipment adaptability are key. Caleva was a true partner, working with us to find a creative solution to a difficult engineering problem.

Erik Koep Chief Executive Officer at Worn Again

We really appreciated your continual input throughout the qualification process and also your recommendations on how to obtain the best possible results from the machines for our future batches.

Shayeba Khan Renata Limited

The [Caleva Multi Lab] machine is very convenient, well designed, and helped my research a lot.

Bakzhan Yergali Nazarbayev University

The system works well and is in particular attractive for us due to its ability to work with extremely small numbers of tablets. We are very satisfied.

Dr Gerhard Winter LMU Munich

We were very pleased with the quality of service that Caleva provided. We sincerely appreciate their attentiveness and the way they conduct their business.

David Haroun Labise

Caleva provided very helpful advice before we finally purchased their equipment. We found their after sales advice very great too.

Ioannis Yannikos Aristotle University

We are very happy with the 2 sets of extruders/spheronizers and appreciate the excellent assistance from the whole Caleva staff.

DIFFUCAP-CHEMOBRAS Quimica e Farmaceutica Ltda, Brazil

Following a training session provided by Caleva, our experienced PhD student rapidly got to grips with the equipment and found it straightforward.

Dr Alexander Edwards University of Reading

The Caleva Powder Extrusion Suite is an invaluable resource to the research at the Bernal Institute, particularly in the activities of the Pharmaceutical Manufacturing Technology Centre (PMTC).

Prof. Gavin Walker University of Limerick

Caleva were extremely nice and knowledgeable through presenting new technology and reliable products that achieve our client’s needs and satisfaction.

Qusay Kareem Knowledge House Engineering Supplies

We have bought Caleva Extruder, Spheronizer and coater systems in Summer 2015. We had a very good training about the instrument by Caleva. They were really flexible.

Ali Nokhodchi University of Sussex

I used the Caleva Model 20 extruder and Caleva MBS 250 spheronizer to develop a multiparticulate prednisone dosage form during my master’s studies at Rhodes University. The instrument was highly efficient and produced spherical pellets with high drug load. Furthermore, the simplified design allowed ease of operation.

Arthur Manda Rhodes University

The Caleva equipment has been very straightforward to set-up and operate. I was able produce suitable spheres on my second attempt, having barely referenced the instruction manuals. [The Mini Coater Dryer] is hugely adjustable and allows the operator a great degree of scope in accommodating almost any kind of coating that might be applied as a liquid, to a solid dose form. All machines are engineered and built to very high standards.

Senior Chemist Kiwicare