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Spheronization is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.
The products produced from this process can be useful in several ways.
Product performance and functionality can be improved or changed to meet a wide range of requirements
Plant procedures can be simplified, to reduce costs or enhance security of operation
The process is well known and widely used in the pharmaceutical, nutraceutical, catalyst, petrochemical, materials science and other industries. Its use is becoming increasingly recognized in other areas of industrial material handling.
Using the CML and MTR in combination we’re learning a lot about our catalyst material. The machines are easy to use, and we have achieved very accurate measurements, giving us precise repeatability. The MTR has been a massive advantage in our research and we’re doing things with the material we didn’t think were possible. The speed and ease of use have allowed us to conduct numerous experiments in a single day - we’ve accumulated vast amounts of data to inform our scale up. Both the CML and MTR are manufactured to a very high standard and are very dependable.Pete Oswald IGTL Technology LTD
[The] Caleva Multi Lab was an important instrument during the initial development of Liqui-Pellet technology, an emerging next generation oral dosage form. The machine has multifunction such as mixing, extruding and spheronizing in a single package that is simple to operate. Although there are different types of approaches in extruding, the extruder in the Caleva Multi Lab is excellent as it works well with the spheroniser to produce uniform size pellets. This is due to the well designed friction plate and capability to adjust the spheronizing speed, which can be set to be very fast. I find not all pelletizers offer such high speed of spheronization.Dr Matthew Lam London Metropolitan University
The University of South Australia purchased the Extruder 20, the Multi Bowl Spheronizer; and the Mini coater/drier from Caleva in 2013 and 2019, respectively. These pieces of equipment have greatly assisted us with our research activities. Their operating systems are user-friendly, owing to the many parameters that can be easily optimized for the different formulations. In addition to this, an efficient cleaning and maintaining procedure are easy to perform.Dr May Song University of South Australia
I have found using Caleva’s Mixer Torque Rheometer (MTR) and the Multi-Lab (granulator, extruder and spheronizer) most valuable in my research where I am reformulating existing active pharmaceutical ingredients into smarter formulations capable of minimising the associated pill burden among patients taking multiple medication as well as improving access to essential medicines.Dr Francis Brako The Medway School of Pharmacy
When transferring a new technology from R&D into production, process flexibility and equipment adaptability are key. Caleva was a true partner, working with us to find a creative solution to a difficult engineering problem.Erik Koep Chief Executive Officer at Worn Again
We really appreciated your continual input throughout the qualification process and also your recommendations on how to obtain the best possible results from the machines for our future batches.Shayeba Khan Renata Limited
The [Caleva Multi Lab] machine is very convenient, well designed, and helped my research a lot.Bakzhan Yergali Nazarbayev University
The system works well and is in particular attractive for us due to its ability to work with extremely small numbers of tablets. We are very satisfied.Dr Gerhard Winter LMU Munich
We were very pleased with the quality of service that Caleva provided. We sincerely appreciate their attentiveness and the way they conduct their business.David Haroun Labise
Caleva provided very helpful advice before we finally purchased their equipment. We found their after sales advice very great too.Ioannis Yannikos Aristotle University
We are very happy with the 2 sets of extruders/spheronizers and appreciate the excellent assistance from the whole Caleva staff.DIFFUCAP-CHEMOBRAS Quimica e Farmaceutica Ltda
Following a training session provided by Caleva, our experienced PhD student rapidly got to grips with the equipment and found it straightforwardDr Alexander Edwards University of Reading
The Caleva Powder Extrusion Suite is an invaluable resource to the research at the Bernal Institute, particularly in the activities of the Pharmaceutical Manufacturing Technology Centre (PMTC)Prof. Gavin Walker University of Limerick
Caleva were extremely nice and knowledgeable through presenting new technology and reliable products that achieve our client’s needs and satisfaction.Qusay Kareem Knowledge House Engineering Supplies
We have bought Caleva Extruder, Spheronizer and coater systems in Summer 2015. We had a very good training about the instrument by Caleva. They were really flexible.Ali Nokhodchi University of Sussex
I used the Caleva Model 20 extruder and Caleva MBS 250 spheronizer to develop a multiparticulate prednisone dosage form during my master’s studies at Rhodes University. The instrument was highly efficient and produced spherical pellets with high drug load. Furthermore, the simplified design allowed ease of operation.Arthur Manda Rhodes University
The Caleva equipment has been very straightforward to set-up and operate. I was able produce suitable spheres on my second attempt, having barely referenced the instruction manuals. [The Mini Coater Dryer] is hugely adjustable and allows the operator a great degree of scope in accommodating almost any kind of coating that might be applied as a liquid, to a solid dose form. All machines are engineered and built to very high standards.Senior Chemist Kiwicare