Welcome to Caleva,

Which process are you interested in?

Click on each tab to see relevant equipment based on your interests

  • light-blue-granulation Mixing & Granulation

    High shear granulation equipment for Mixing and granulation

  • Variable-Density Extrusion

    Equipment that can extrude as little as 10g of material, all the way up to 150kg per hour 

  • red-spheres reduced Spheronization

    From lab scale spheronization equipment up to full production size. Making scale up easy and consistent

  • Hand-with-pellets Coating/drying tablets and pellets

    Coat from a single tablet up to 150 tablets in a single batch

  • Picture17-250479-edited Rheology of wet masses

    Quantify the characteristics of your wet mass to correctly determine the end point of your granulation


Deagglomerate and mix or blend your small batch samples

Batch size: 10 - 50 g

small-granulator-from-caleva-for-50g-batch-size-part-of-the-caleva-multi-lab.add-the-extruding-and-spheronizing-attachments-as-and-when-you-need-them_med

The Mixer Granulator Blender (MGB)

Mix small samples on this benchtop machine.

Proven ability to mix, blend, de-agglomerate and granulate a wide range of different materials in small batches. 

Demonstrated efficacy with powder batch sizes from about 10 g to 50 g depending on the bulk density of the sample

Liquids, creams and fluids have been demonstrated to be blended with batch sizes ranging from 20 ml to 170 ml

View the MGB

 


Mix/granulate, Extrude and Spheronize all in one base unit

Batch size: 10 - 50g

spheronizer-for-small-batches-for-university-teaching-part-of-the-caleva-multi-lab-unit-which-is-ideal-for-student-hands-on-involvement_med

The Caleva Multi Lab (CML)

The CML possesses all of the same abilities as the MGB listed above, but has the added benefits of being able to extrude and spheronize your product.

Works with batch sizes from 10 to 50 g

Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.

Turn powder into pellets in under 15 minutes.

View the CML

 


 


Mix/granulate, Extrude and Spheronize all in one base unit

Batch size: 10 - 50g

caleva-multi-lab-with-mini-screw-extruder-attachment-shipping-now_lrg

The Caleva Multi Lab (CML)

The CML is capable of 3 processes, mixing, extrusion and spheronization.

It has a remarkably small "footprint" just larger than a sheet of A3 paper

Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.

Turn powder into pellets in under 15 minutes.

View the CML

 


Recommended for your formulation development when
flexibility is important to you

Batch Size: 100 g to 1.5 kg

with-the-variable-density-extruder-from-caleva-you-can-increase-the-active-material-in-your-unit-dose-in-clinical-trials_med

The Variable Density Extruder (VDE)

Multiple die hole diameter and depth options for ultimate control over your extrudate properties, whilst also allowing you to explore variable density

Suitable for a wide variety of industries including pharmaceuticals, ceramics, catalysts and others. 

Water jacket option for warming or cooling available

View the VDE

 

 

 


Designed to ease your scale-up from development to production

Batch size: 150g to 1.5kg

caleva-extruder-20-comes-complete-with-safety-cover-loading-tray-and-productino-collection-tray-so-work-can-begin-immediately_med

The Extruder 20 (E20)

Low pressure screen extrusion system designed for easy scale up

Suitable for food, pharmaceutical, nutraceutical or other similar applications

Has the option of interchangeable screens, different die hole sizes and variable screen heights.

View the E20

 


Fast turnaround leading to increased efficiency

Average hourly throughput: 50 kg (Formulation dependent)

caleva-extruder-35-part-of-the-100-kg-per-hour-pelleting-system_lrg

The Extruder 35 (E35)

The perfect scale up option from the E20

Easy to clean

Works with a range of industries such as pharmaceutical, catalyst manufacture, petrochemicals and ceramics

View the E35

 


Our largest capacity extruder

Average hourly throughput: 150 kg (Formulation dependent)

Twin-screw-variable-density-extruder-for-commercial-manufacture

The Variable Density Twin Screw Extruder (TSE)

Designed for continuous or intermittent production within industrial environments.

The twin-screw design provides a consistent and effective extrusion action

View the TSE

 


 


Mix/granulate, Extrude and Spheronize all in one base unit

Bacth size: 10 - 50 g

spheronizer-for-small-batches-for-university-teaching-part-of-the-caleva-multi-lab-unit-which-is-ideal-for-student-hands-on-involvement_med

The Caleva Multi Lab (CML)

The CML is capable of 3 processes, Mixing, extrusion and spheronization.

Multiple different disk patterns are available to increase your chances of formulation development success.

Turn powder into pellets in under 15 minutes.

View the CML

 


Flexible batch size spheronization system for your bench-top

Batch size: 50 g - 1.5 kg

the-renowned-caleva-multi-bowl-spheronizer-is-the-industry-standard-and-with-its-rnage-of-optional-bowls-can-be-made-suiable-for-batches-from-1-gram-to-1.5-kilograms_med

The Multi Bowl Spheronizer (MBS)

Designed for ease of scale-up to cost effective manufacture

4 bowl sizes available, so that you can work with the widest possible range of batch sizes

View the MBS

 


Ideal for small scale production

Average hourly throughput: 50 kg (Formulation dependent)

caleva-extruder-35-and-spheronizer-380-for-up-to-50-kg-per-hour-pellets_lrg_lrg

The Spheronizer 380 (S380)

Produces high quality results in a range of industries from animal feed and pharmaceutical products to ceramics and more.

Quick and easy disassembly for cleaning, allowing for quick turn around to keep your production process flowing smoothly

View the S380

 


Part of the 100 kg per hour Extrusion and Spheronization System

Average hourly throughput: 100 kg (Formulation dependent)

S500

The Spheronizer 500 (S500)

Has a relatively small "footprint" making it easy to store and easy to fit into smaller areas

Multiple disk patterns are available, including dust reducing radial designs

Lockable wheels on it's base for easy movement and positioning.

View the S500

 


Caleva's largest production spheronizer

Average hourly throughput: 150 kg (Formulation dependent)

S700

The Spheronizer 700 (S700)

Designed for continuous or intermittent production within industrial environments.

Air blast cleaning technology to enhance efficiency during continuous operation

Batch operation with fully automatic discharge

View the S700

 


 


Coat particles from 0.5mm to about 10mm in diameter

Batch size:

Tablets/Capsules: 1 to 150

Pellets: 5 - 60 g

caleva-mini-coater-drier

The Mini Coater Dryer (MCD)

Achieve excellent uniformity in your batches whilst reducing your product cost.

Overcome limited product availability by coating extremely small amounts of product

Produce results quickly, easily and efficiently

View the MCD

 


 

 

 


Enhance reproducibility among formulations

Sample size required: 10 - 50 g

optimize-formulation-characteristics-and-research-powder-binder-relationships-easily-using-the-mixer-torque-rheometer-mtr_lrg-1

The Mixer Torque Rheometer (MTR)

The MTR allows you to save time and money in your formulation development

The only repeatable and reliable way to quantify your wet mass to correctly determine the end point of your granulation

Learn how your formulations can be affected by under or over mixing

View the MTR

 


 

  • light-blue-granulation Mixing & Granulation

    High shear granulation equipment for Mixing and granulation


  • Deagglomerate and mix or blend your small batch samples

    Batch size: 10 - 50 g

    small-granulator-from-caleva-for-50g-batch-size-part-of-the-caleva-multi-lab.add-the-extruding-and-spheronizing-attachments-as-and-when-you-need-them_med

    The Mixer Granulator Blender (MGB)

    Mix small samples on this benchtop machine.

    Proven ability to mix, blend, de-agglomerate and granulate a wide range of different materials in small batches. 

    Demonstrated efficacy with powder batch sizes from about 10 g to 50 g depending on the bulk density of the sample

    Liquids, creams and fluids have been demonstrated to be blended with batch sizes ranging from 20 ml to 170 ml

    View the MGB

     


    Mix/granulate, Extrude and Spheronize all in one base unit

    Batch size: 10 - 50g

    spheronizer-for-small-batches-for-university-teaching-part-of-the-caleva-multi-lab-unit-which-is-ideal-for-student-hands-on-involvement_med

    The Caleva Multi Lab (CML)

    The CML possesses all of the same abilities as the MGB listed above, but has the added benefits of being able to extrude and spheronize your product.

    Works with batch sizes from 10 to 50 g

    Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.

    Turn powder into pellets in under 15 minutes.

    View the CML

     


     

  • Variable-Density Extrusion

    Equipment that can extrude as little as 10g of material, all the way up to 150kg per hour 


  • Mix/granulate, Extrude and Spheronize all in one base unit

    Batch size: 10 - 50g

    caleva-multi-lab-with-mini-screw-extruder-attachment-shipping-now_lrg

    The Caleva Multi Lab (CML)

    The CML is capable of 3 processes, mixing, extrusion and spheronization.

    It has a remarkably small "footprint" just larger than a sheet of A3 paper

    Multiple different extrusion screw and die combinations are available to increase your chances of formulation development success.

    Turn powder into pellets in under 15 minutes.

    View the CML

     


    Recommended for your formulation development when
    flexibility is important to you

    Batch Size: 100 g to 1.5 kg

    with-the-variable-density-extruder-from-caleva-you-can-increase-the-active-material-in-your-unit-dose-in-clinical-trials_med

    The Variable Density Extruder (VDE)

    Multiple die hole diameter and depth options for ultimate control over your extrudate properties, whilst also allowing you to explore variable density

    Suitable for a wide variety of industries including pharmaceuticals, ceramics, catalysts and others. 

    Water jacket option for warming or cooling available

    View the VDE

     

     

     


    Designed to ease your scale-up from development to production

    Batch size: 150g to 1.5kg

    caleva-extruder-20-comes-complete-with-safety-cover-loading-tray-and-productino-collection-tray-so-work-can-begin-immediately_med

    The Extruder 20 (E20)

    Low pressure screen extrusion system designed for easy scale up

    Suitable for food, pharmaceutical, nutraceutical or other similar applications

    Has the option of interchangeable screens, different die hole sizes and variable screen heights.

    View the E20

     


    Fast turnaround leading to increased efficiency

    Average hourly throughput: 50 kg (Formulation dependent)

    caleva-extruder-35-part-of-the-100-kg-per-hour-pelleting-system_lrg

    The Extruder 35 (E35)

    The perfect scale up option from the E20

    Easy to clean

    Works with a range of industries such as pharmaceutical, catalyst manufacture, petrochemicals and ceramics

    View the E35

     


    Our largest capacity extruder

    Average hourly throughput: 150 kg (Formulation dependent)

    Twin-screw-variable-density-extruder-for-commercial-manufacture

    The Variable Density Twin Screw Extruder (TSE)

    Designed for continuous or intermittent production within industrial environments.

    The twin-screw design provides a consistent and effective extrusion action

    View the TSE

     


     

  • red-spheres reduced Spheronization

    From lab scale spheronization equipment up to full production size. Making scale up easy and consistent


  • Mix/granulate, Extrude and Spheronize all in one base unit

    Bacth size: 10 - 50 g

    spheronizer-for-small-batches-for-university-teaching-part-of-the-caleva-multi-lab-unit-which-is-ideal-for-student-hands-on-involvement_med

    The Caleva Multi Lab (CML)

    The CML is capable of 3 processes, Mixing, extrusion and spheronization.

    Multiple different disk patterns are available to increase your chances of formulation development success.

    Turn powder into pellets in under 15 minutes.

    View the CML

     


    Flexible batch size spheronization system for your bench-top

    Batch size: 50 g - 1.5 kg

    the-renowned-caleva-multi-bowl-spheronizer-is-the-industry-standard-and-with-its-rnage-of-optional-bowls-can-be-made-suiable-for-batches-from-1-gram-to-1.5-kilograms_med

    The Multi Bowl Spheronizer (MBS)

    Designed for ease of scale-up to cost effective manufacture

    4 bowl sizes available, so that you can work with the widest possible range of batch sizes

    View the MBS

     


    Ideal for small scale production

    Average hourly throughput: 50 kg (Formulation dependent)

    caleva-extruder-35-and-spheronizer-380-for-up-to-50-kg-per-hour-pellets_lrg_lrg

    The Spheronizer 380 (S380)

    Produces high quality results in a range of industries from animal feed and pharmaceutical products to ceramics and more.

    Quick and easy disassembly for cleaning, allowing for quick turn around to keep your production process flowing smoothly

    View the S380

     


    Part of the 100 kg per hour Extrusion and Spheronization System

    Average hourly throughput: 100 kg (Formulation dependent)

    S500

    The Spheronizer 500 (S500)

    Has a relatively small "footprint" making it easy to store and easy to fit into smaller areas

    Multiple disk patterns are available, including dust reducing radial designs

    Lockable wheels on it's base for easy movement and positioning.

    View the S500

     


    Caleva's largest production spheronizer

    Average hourly throughput: 150 kg (Formulation dependent)

    S700

    The Spheronizer 700 (S700)

    Designed for continuous or intermittent production within industrial environments.

    Air blast cleaning technology to enhance efficiency during continuous operation

    Batch operation with fully automatic discharge

    View the S700

     


     

  • Hand-with-pellets Coating/drying tablets and pellets

    Coat from a single tablet up to 150 tablets in a single batch


  • Coat particles from 0.5mm to about 10mm in diameter

    Batch size:

    Tablets/Capsules: 1 to 150

    Pellets: 5 - 60 g

    caleva-mini-coater-drier

    The Mini Coater Dryer (MCD)

    Achieve excellent uniformity in your batches whilst reducing your product cost.

    Overcome limited product availability by coating extremely small amounts of product

    Produce results quickly, easily and efficiently

    View the MCD

     


     

     

     

  • Picture17-250479-edited Rheology of wet masses

    Quantify the characteristics of your wet mass to correctly determine the end point of your granulation


  • Enhance reproducibility among formulations

    Sample size required: 10 - 50 g

    optimize-formulation-characteristics-and-research-powder-binder-relationships-easily-using-the-mixer-torque-rheometer-mtr_lrg-1

    The Mixer Torque Rheometer (MTR)

    The MTR allows you to save time and money in your formulation development

    The only repeatable and reliable way to quantify your wet mass to correctly determine the end point of your granulation

    Learn how your formulations can be affected by under or over mixing

    View the MTR

     


     

Are you interested in a live demonstration of any of our equipment?

If so, please click the image below to see how to arrange your demonstration.

LIVE DEMO-4

 

What is Spheronization?

Spheronization is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.

You can find a more in depth explanation inside this document below

 

pdf download of brief guide to spheronization

The products produced from this process can be useful in several ways

Product performance and functionality can be improved or changed to meet a wide range of requirements

Plant procedures can be simplified, to reduce costs or enhance security of operation

The process is well known and widely used in the pharmaceutical, nutraceutical, catalyst, petrochemical, materials science and other industries. Its use is becoming increasingly recognized in other areas of industrial material handling.

 

 

 

 

 Download a pdf copy of our guide
 Or view the full guide to spheronization in your browser

 

Testimonial

Caleva were extremely nice and knowledgeable through presenting new technology and reliable products that achieve our client’s needs and satisfaction.

Qusay Kareem Knowledge House Engineering Supplies

Caleva provided very helpful advice before we finally purchased their equipment. We found their after sales advice very great too.

Ioannis Yannikos Aristotle University

We were very pleased with the quality of service that Caleva provided. We sincerely appreciate their attentiveness and the way they conduct their business.

David Haroun Labise

We are very happy with the 2 sets of extruders/spheronizers and appreciate the excellent assistance from the whole Caleva staff.

DIFFUCAP-CHEMOBRAS Quimica e Farmaceutica Ltda

Following a training session provided by Caleva, our experienced PhD student rapidly got to grips with the equipment and found it straightforward

Dr Alexander Edwards University of Reading

The Caleva Powder Extrusion Suite is an invaluable resource to the research at the Bernal Institute, particularly in the activities of the Pharmaceutical Manufacturing Technology Centre (PMTC)

Prof. Gavin Walker University of Limerick

The system works well and is in particular attractive for us due to its ability to work with extremely small numbers of tablets. We are very satisfied.

Dr Gerhard Winter LMU Munich

We have bought Caleva Extruder, Spheronizer and coater systems in Summer 2015. We had a very good training about the instrument by Caleva. They were really flexible.

Ali Nokhodchi University of Sussex

I used the Caleva Model 20 extruder and Caleva MBS 250 spheronizer to develop a multiparticulate prednisone dosage form during my master’s studies at Rhodes University. The instrument was highly efficient and produced spherical pellets with high drug load. Furthermore, the simplified design allowed ease of operation.

Arthur Manda Rhodes University