---
title: Formulation development with Caleva
description: The process of spheronization consists of four key steps.  The key stages are described here by Caleva.
---

[Caleva Knowledge Base ](https://www.caleva.com/knowledge-base)

# [Formulation development with Caleva](https://www.caleva.com/knowledge-base/formulation-development-with-caleva)

 Written by [Caleva](https://www.caleva.com/knowledge-base/author/caleva) | 28-Apr-2021 10:50:38

The process of spheronization consists of four key steps:-

- To optimize and achieve the right binder addition  & mixing time for your formulation
- Mixing or granulation - a mixer or granulator is required
- Extrusion - an extruder is required
- Spheronization - a spheronizer is required
- Drying and possibly coating - a coater and drier may be required

This is all made simple by the Caleva suite of R&D equipment shown in the section below.

## Quantify the Characteristics of your Formulation

- Reduce your formulation development time
- Optimize the characteristics of your formulation?
- Can you confirm that the same product from different suppliers behaves differently in your formulations?
- Would it be useful to be able to quantify the characteristics of samples taken from your granulator?

<https://www.caleva.com/knowledge-base/caleva-mixer-torque-rheometer-the-importance-of-mixing-time-for-your-formulation-development-and-production>

## [Mixer Torque Rheometer](https://www.caleva.com/mtr)

## Mix, Extrude, Spheronize and Analyse with a Single Bench-Top Unit

- Save benchtop space, time and materials with small batch sizes of 10 - 40 g
- Fast processing times means you can go from powder to pellets in 20 minutes or less 
- Various bowls, blades, extruder screws, barrels, and die options available for different materials
- Multi Lab Classic's software and accessories can be upgraded after purchase to the Multi Lab Scientific 
- Multi Lab Scientific has automated data acquisition, recipe management and automatic operation, motor load % reports, temperature monitoring and data export for in-depth analysis.

## <https://www.caleva.com/multi-lab-scientific>

## [Multi Lab Scientific](https://www.caleva.com/multi-lab-scientific)

 

## Quickly Coat or Dry a Few Tablets, Capsules or Pellets

- From a single tablet up to about 50 tablets
- From a few grams to about 60 grams of small pellets 
- From a single capsule to a "small handful" of pellets
- You can reduce the amounts of ingredients used whilst still producing meaningful results

## <https://www.caleva.com/mini-coater-classic>

## [Mini Coater Classic](https://www.caleva.com/mini-coater-classic)

 

 

[View full post](https://www.caleva.com/knowledge-base/formulation-development-with-caleva)

```json
{
  "@context" : "http://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "Caleva"
  },
  "dateModified" : "2026-03-12T15:57:31.825Z",
  "datePublished" : "2021-04-28T10:50:38Z",
  "headline" : "Formulation development with Caleva",
  "image" : {
    "@type" : "ImageObject",
    "height" : 534,
    "url" : "https://cdn2.hubspot.net/hubfs/4021250/Caleva-spheronizer-700-1.jpg",
    "width" : 800
  },
  "mainEntityOfPage" : "https://www.caleva.com/knowledge-base/formulation-development-with-caleva",
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "height" : 60.0,
      "url" : "https://cdn2.hubspot.net/hubfs/4021250/Email%20Signatures/logo-email-signature.jpg",
      "width" : 60.000004
    },
    "name" : "Knowledge Base"
  }
}
```